"2005-09-27T09:30:30Z"^^ . "2005-09-27T09:30:30Z"^^ . "Organic molecules (cf. coenzymes) or ions (usually metal ions) that are required by an enzyme of its activity. A cofactor binds with its associated protein (apoenzymes), which is functionally inactive, to form the active enzyme (source: IUPAC)"@en .