_:b1214537 _:b1214536 . _:b1214536 . . . _:b1214537 . "acts upstream of or within" . "c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process." . . "affects" . "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway." . _:b1214536 . _:b1214537 .